Background. Artesunate is one of the most potent, rapidly acting and therapeutically versatile antimalarial drugs. Its efficacy is\nhampered by poor aqueous solubility and stability resulting in low oral bioavailability. Recent efforts to nanoformulate artesunate\nhave shown great potential of improving its dissolution profile and bioavailability.However, no study has yet been done to investigate\nthe intestinal permeability of these nanoformulations, which is a critical determinant of systemic absorption. Objective of the Study.\nThemain aimof the study was to determine the intestinal permeability of artesunate-loaded solid lipid nanoparticles (SLN). Method.\nThemicroemulsion dilution technique was used to fabricate artesunate-loaded solid lipid nanoparticles. In vitro drug release studies\nwere performed at pH 1.2 and 6.8 using the dialysis membrane method.Theeverted gut sac method was used to assess the intestinal\npermeability of the prepared nanoparticles. Results. The average particle size was 1109 nm and the polydispersity index (PDI) was\n0.082. The zeta potential was found to be âË?â??20.7mV. The encapsulation efficiency of the solid lipid nanoparticles obtained was\n51.7%. At both pH 1.2 and 6.8, pure artesunate was rapidly released within the first 30 mins while the SLN showed a biphasic\nrelease pattern with an initial burst release during the first hour followed by a prolonged release over time. The rate of drug release\nincreased with increasing pH. The apparent permeability (
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